Just thought I would post this since I didnt know until I looked it up. I generally have a rule that while taking anavar (or any oral AAS) that I wont take any other medication. Allergys have been hitting us pretty hard here in Dallas and I was about to take some Benadryl because I just couldnt stand it anymore. I looked it up online and found out that Benadryl also is metabolized in the liver. Just thought I would post it in case anyone else was having allergies and thought about taking it. IMO its best to avoid putting any further strain on your liver when taking orals so thought I would share the info since sometimes we tend to think of OTC stuff as harmless. Chelsea