ok ladies.. several of us have used different preparations of yohimbine.. in powder form (HCL) via dmso, thimocase or plo gel... or pill form... It has proven to spot reduce as well as shed extra fat... It can however hold water and create other side effects which i will also discuss...
Granted yohimbine is medically used for erectile dysfunction in men, it has fat loss capabilities... Yohimbine is an Alpha-2 antagonist aka blocker... Here is some information for everyone to better understand the role yohimbine can play in fat loss. ..

First.. what and where are Alpha-2 receptors...

Alpha-2 receptors are common in sites of the body that tend to accumulate fat; abdomen, breasts, buttocks and thighs. When exposed to circulating norepinephrine and epinephrine, alpha-2 receptor sites inhibit lipolysis (the release of fatty acids), while the beta receptors stimulate lipolysis. Basically, epinephrine and norepinephrine stimulate the release of fatty acids from adipose tissue into the blood stream. Once in the blood stream, fatty acids are usually rapidly oxidized (however, much more efficiently on an empty stomach). Generally, when fatty acid blood concentration is high, it favors fat storage.

What yohimbine can do...

Yohimbine blocks the alpha-2 receptors which is useful during weight loss to free up epinephrine and norepinephrine, making more available to stimulate beta receptor sites, resulting in a higher rate of lipolysis. Also, yohimbine, through its alpha 2-adrenergic receptor antagonist activity, has been shown to increase levels of norepinephrine in the blood stream.

From an ISSA study (my training cert) - Galitzky and coworkers observed during their 14- day study of yohimbine treatment that lipid-mobilizing effects were sustained during this study period. This research collaborated their earlier observations found using yohimbine as a lipid-mobilizing agent, as well as from the research of Lafontan and coworkers. Yohimbine is a selective alpha 2 antagonist and can maximize NE levels, thus maximizing fat loss, particularly in female problem areas.


Yohimbine vs. yohimbe (taken from 1fast400)

"Quite a bit of confusion seems to exist about the difference between Yohimbine and yohimbe. Yohimbine is the principal alkaloid from the herb P. yohimbe. However, there are 31 other yohimbane alkaloids that can be present in herbal yohimbe preparations. Some of these have different and unknown selectivities and potencies (and thus, effects) at the adrenergic receptors (8, 9) -- in addition, these preparations vary greatly from brand to brand and even from batch to batch, as no standardization for extraction exists. In fact, a recent investigation found that most over the counter preparations have little to no actual yohimbine (10). And, even in the more potent preparations, most people find a higher degree of undesirable effects with the herb vs. pure Yohimbine Hydrochloride"


Dosing of yohimbine HCL: 10mgs per 100lbs or (0.2mg/kg of bodyweight) other yohimbe/herbal formulas vary

side effects: dizziness, anxiety, skin flushing, headaches, hyperstimulation and nausea.. Most common and most important to monitor: rapid increase in heart rate during cardiovascular activity

***Best to be taken first thing in the morning on an empty stomach.. Here is why...
The lipid-mobilizing effects of yohimbine are completely negated when administered with or after a meal. Yohimbine increases insulin secretion during glucose stimulation (a meal). Yohimbine when takin with a meal, causes increased insulin secretion which blunts its lipid mobilizing effects... However, in fasting conditions, yohimbine does not increase insulin levels. These results demonstrate the importance of nutritional status when administering a 2-antagonists as lipid-mobilizing agents. Yohimbine administration first thing in the morning on an empty stomach could be followed in two to three hours by ingestion of a high-protein, high-fat meal... At least this is the MOST optimal way to utilize yohimbine.


Oral yohimbine can come in pharmaceutical grade capsules OR powder.. Powder can be combined with a dmso, plo etc for a topical use.. also great for spot reductions!!! Oral is more potent and more precautions should be used...

So there you have it Please feel free to add anything i may have missed... personal experiences etc!! Enjoy!!

luv super

i usually take Yohimbine with an eca... granted you will get more of a rush and more jitters, but they do work well together... be prepared to sweat your ass off and DRINK a lot of water!!! The key with any type thermogenic is to keep hydrated! Pok.. keep in mind that 10mgs per 100lbs is an AVERAGE... you might not be able to tolerate that much.. the key is to listen to your body and feel it out... But 2.7 is quite low, imo i would use 2 at a dosage... Yohimbine as you can read above is quite insulin sensitive... so the key here with timing is to take yohimbine after not eating for at least an hour - 2 hours.. first thing in the morning is the most potent obviously because you have been fasting for about 608 hours during sleep, so it will work the best.... i like to wake up, take my stack, go do cardio and then eat... That i felt to be the most potent way!!! but if you want to break it up, i would suggest take 1-2 in the morning first thing.. then 1-2 pre workout/ afternoon (but only after 1-2 hours after your last meal) does that help??

Reply » Yohimbine thread :) due to popular demand lol

SG, that's the single best post on yohimbine I've ever read. Thank you.

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