Don't believe so

Proviron has essentially no use as an anti-aromatase... and definitely not an anti-estrogen. It doesn't bind at the estrogen receptor at all... and only very very weakly at the testosterone binding site on the aromatase enzyme. Proviron binds very tightly to sex hormone binding globulin (SHBG). SHBG normally binds up almost all the free testosterone in your system, severely limiting it's bioavailability. Most of that test is then metabolized and does nothing. Proviron binds up all the SHBG so that it can't bind to test... which means that free testosterone levels jump way up. This means alot more binding to the aromatase enzyme... which means more bang for your buck. Of the test you shoot, far less than 10% of it ever even does much of anything... and even less of it actually makes it to the androgen receptor. Most of it is metabolized in the liver, or used as a precursor for other sterol based hormones. Proviron is great for getting more out of your money... much better results from far lower doses of androgens... but that's about it.

As far as binding to the aromatase like arimidex or femara. .. it doesn't do much of anything. The binding it so weak, it's not even considered statistically significant... much less clinically significant.

No.

No. But when proviron binds to SHBG, then that SHBG molecule can't bind to testosterone (rendering it useless). I think that literally lowering the SHBG, if we could do that, might be much more beneficial. Oh well.

No.

lonewing's post ablove is good.

lonewing and mranak,

I think I have to disagree with you on proviron's effect on preventing gyno. proviron binds to the aromatase enzyme very strongly and prevents testosterone from interacting with it. not only is this medically documented, but I have also found this true in a real world application. I have run the same brand test at the same dosage for 2 different cycles. The only difference between the 2 was that I included proviron in 1 of the cycles at 50mg per day. I developed puffy nips around week 6 in the cycle without proviron. On the other hand, in the cycle with proviron, I had no such problems for the duration of the 16 week cycle. If proviron has no effect on estrogen then explain to me why I got the results that I got.

P.S. I am not arguing here at all. I think we can all learn alot by this discussion. Thanks guys

I'm not saying it has no effect at all,just that it's very minimal.And shouldn't be use for gyno prevention and PCT alone.Maybe your body responds to the minimal effects of it.Mine dose not.So like most gear,everybody's different and responds different to different compounds.


I don't argue either,thats why I don't post up here much.
Thats probably the first time Mranak agreed with me.lol

Good talkin with ya