I like the ACE, fewer side for me. If an ACE don't hold I then combine ACE with Ca blocker same reason very few sides. Alpha, Beta, Alpha & Beta agonist will fatigue the hell out of you. They work in the autonomic NS by way of invoking a parasympathetic responses. HCT will toast my joints by removing fluid from the bursae. I request ACE or Ca blacoker only, the other promote exercise intolerance from centrally acting on parsympathetic system. You can look at like this, it would be like trying to train while being drunk because peripheral NS depression.